Fig. 6: Pathogen apathy stems from systemic serotonin depletion.
From: Serotonin deficiency from constitutive SKN-1 activation drives pathogen apathy
Pathogen leaving behavior of (A) tph-1lf and (B) pah-1lf animals. C tph-1lf pah-1lf double mutants display pathogen apathy like skn-1gf mutants which is alleviated with supplementation of serotonin (D). Each of the food choice assays comprised of N ≥ 3 (with ≥ 150 worms per biological replicate per strain/condition) and analyzed via two-way ANOVA test; **(p < 0.01) ***(p < 0.001) ****(p < 0.0001). Individual “p” value numbers for the comparisons within each graph is placed above the respective comparison bars in the graph. Source data for all behavioral responses are provided as a Source Data file 1.
