Fig. 7: Serotonin depletion limits pathogen resistance.
From: Serotonin deficiency from constitutive SKN-1 activation drives pathogen apathy
Survival analysis of (A) WT and (B) skn-1gf animals with and without serotonin supplementation on PA14 fast kill assay plates. C Survival analysis of tph-1lf, pah-1lf, and tph-1lf pah-1lf on PA14-seeded fast kill assay plates. Each of the fast kill assays comprised N ≥ 3 (with ≥ 150 worms per biological replicate per strain/condition) and analyzed via two-way ANOVA test; **(p < 0.01) ***(p < 0.001) ****(p < 0.0001). Individual “p” value numbers for the comparisons within each graph are placed above the respective comparison bars in the graph. Source data for pathogen survival data are provided as a Source Data file 4.
