Fig. 2: The Manhattan plots for GWAS meta-analyses of two thyroid-related hormones. | Nature Communications

Fig. 2: The Manhattan plots for GWAS meta-analyses of two thyroid-related hormones.

From: Genome-wide association studies of thyroid-related hormones, dysfunction, and autoimmunity among 85,421 Chinese pregnancies

Fig. 2

A TSH levels, B FT4 levels. After performing GWAS analysis of Longgang Study and Baoan Study using plink2.0, meta-analysis was subsequently completed using METAL software. The P value threshold for determining whether SNP signals were significant was adopted from the Bonferroni-corrected threshold commonly used for GWAS analysis(P < 5 × 10−8). The x-coordinate of the SNPs in the plot represents their position on each chromosome when the y-coordinate implies their P value (−log10 scale) of the association test. The black dotted horizontal line indicates the significant threshold for the genome-wide association test (i.e., 5 × 10−8). Genomic loci containing phenotype-associated variants previously reported in the GWAS catalog are colored in black, while novel loci are colored in red.

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