Fig. 6: The association between thyroid-related traits during pregnancy and birth outcomes. | Nature Communications

Fig. 6: The association between thyroid-related traits during pregnancy and birth outcomes.

From: Genome-wide association studies of thyroid-related hormones, dysfunction, and autoimmunity among 85,421 Chinese pregnancies

Fig. 6

A Prospective observational analysis. In each grid, the upper left triangle shows the regression coefficients for the phenotypic associations in the Longgang cohort, while the lower right triangle shows those for the Baoan cohort. We completed the analysis of phenotypic associations between gestational phenotypes and thyroid traits using generalized linear model (glm function in R 4.3.2). B Mendelian randomization. The upper left triangle of each grid indicates the regression coefficients of the phenotypic association results in the Longgang cohort, while the lower right triangle indicates the regression coefficients of the phenotypic association results in the Baoan cohort. A, B, if there is a significant difference (P < 0.05) between the effect estimates and 0, the middle of the triangle is labeled with a red asterisk (P < 0.05 and P > 0.05/14) or two red asterisks (P <0.05/14). C Mendelian randomization analysis for casual associations between TSH and thyroid cancer and between TSH and gestational duration. TSH and gestational duration are based on summary statistics from the meta analysis of the Baoan and Longgang Study (Sample size NTSH = 67,471, and Ngestational duration = 51,592). The results of the IVW, IVWRE, MR Egger, Simple mode, and Weighted mode methods are based on the analysis of the IVs excluded by MR PRESSO. The crosshairs on the plots represent the effect sizes(beta) and 95% confidence intervals for each SNP-TSH or SNP-outcome association. Abbreviation: IVW inverse-variance weighted, IVWRE inverse-variance weighted with multiplicative random effects. TSH TSH levels within reference range during pregnancy, FT4 FT4 levels within reference range during pregnancy, SHO subclinical hypothyroidism during pregnancy, ISH isolated hypothyroxinemia during pregnancy, OHP overt hyperthyroidism during pregnancy, SHP subclinical hyperthyroidism during pregnancy, TPOAb TPOAb levels, Tb (+) TPOAb positivity during pregnancy and EUTb(+): TPOAb positivity with normal functioning thyroid (i.e., euthyroid).

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