Fig. 7: The results of bidirectional Mendelian randomization analysis between thyroid traits during pregnancy and thyroid-related diseases in middle-aged and elderly people. | Nature Communications

Fig. 7: The results of bidirectional Mendelian randomization analysis between thyroid traits during pregnancy and thyroid-related diseases in middle-aged and elderly people.

From: Genome-wide association studies of thyroid-related hormones, dysfunction, and autoimmunity among 85,421 Chinese pregnancies

Fig. 7

The upper left triangle of each grid indicates the results of forward MR (thyroid traits as exposure variables), while the lower right triangle indicates the results of reverse MR (thyroid traits as outcome variables). The black color of the triangle indicates that the result is not available (due to an insufficient number of IVs). Abbreviation: TSH TSH levels within reference range during pregnancy, FT4 FT4 levels within reference range during pregnancy, SHO subclinical hypothyroidism during pregnancy, ISH isolated hypothyroxinemia during pregnancy, OHP overt hyperthyroidism during pregnancy, SHP subclinical hyperthyroidism during pregnancy, TPOAb TPOAb levels, Tb(+) TPOAb positivity during pregnancy and EUTb(+) TPOAb positivity with normal functioning thyroids (i.e., euthyroid).

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