Fig. 8: 3D protein structure analysis of GshB allelic variants underlying BD-1.2 and BD-2 lineage evolution and clinical symptoms. | Nature Communications

Fig. 8: 3D protein structure analysis of GshB allelic variants underlying BD-1.2 and BD-2 lineage evolution and clinical symptoms.

From: Core and accessory genomic traits of Vibrio cholerae O1 drive lineage transmission and disease severity

Fig. 8

A Violin plot indicating the distribution of the diarrhoea duration score (0: no diarrhoea, 1: <1day, 2: 1–3 days, 3: 4–6 days and 4: 7–9 days) for the isolates containing either Thr93 (T) or Ile93 (I). Statistical significance was tested with a two-sided Mann Whitney U test, p-value is shown. B Violin plot indicating the distribution of the number of stools score (0: <3 times, 1: 3–5 times; 2: 6–10 times; 3: 11–15 times; 4: 16–20 times; 5: 21+ times) for the isolates containing either Thr93 (T) or Ile93 (I). Statistical significance was tested with a two-sided Mann Whitney U test, p-value is shown. C The bar graph displays the number of isolates in the two BD lineages associated Thr93 (T) or Ile93 (I). D 3D structures of GshB (AlphaFold) with Thr93 and coloured by functional domains. Amino acid residues (Asp92, Ile96, and Tyr97) interacting with Thr93 (green) are shown in sticks models. E 3D structures of GshB (AlphaFold) with Ile93 and coloured by functional domains. Amino acid residues interacting with Ile93 (orange) are shown in sticks models.

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