Fig. 6: Model of the influence of USP50 on WRN-FEN1, RECQL4/5, and DNA2 during replication.
From: USP50 suppresses alternative RecQ helicase use and deleterious DNA2 activity during replication
A USP50 promotes the recruitment of WRN-FEN1 to stalled replication structures. Helicase and nuclease competent WRN (dark blue), and GEN and WRN interaction-competent FEN1 (light blue) can rescue the lack of USP50 to promote ongoing replication and suppress DSB foci. B Without USP50, increased RECQL4 and RECQL5 (dark blue) and DNA2 (light blue) result in extended resection and MUS81-dependent DNA breaks. DNA DSBs are more common near CG-rich sequences.
