Fig. 5: In vivo investigation of the antitumor efficiency. | Nature Communications

Fig. 5: In vivo investigation of the antitumor efficiency.

From: Biodegradable copper-iodide clusters modulate mitochondrial function and suppress tumor growth under ultralow-dose X-ray irradiation

Fig. 5

a The time-dependent distribution of Cu-I@BSA-EBGA in plasma within 24 h. b The tumor fluorescence intensity changes at different time points after tail vein injection of Cu-I@BSA-EBGA. c The fluorescence intensities of major organs of mice sacrificed at 24 h post-injection of Cu-I@BSA-EBGA. d Illustration of in vivo therapy process. e Tumor volume changes of HepG2-tumor bearing mice after different treatments. V represents the tumor volume at different time points, and V0 represents the tumor volume at Day 0. f Tumor volumes on Day 14 after treatments. V represents the tumor volume at different time points, and V0 represents the tumor volume at Day 0. g, h Tumor inhibition rates were calculated using tumor volumes (g) and tumor weights (h) on Day 14 after the treatments (n = 6 mice/group). i Representative H&E staining images of tumor tissues after different treatments (Scale bar: 50 μm). Data are presented as mean ± SD for (a–c) and (e–h). Statistical differences were assessed using one-way ANOVA, and were defined as ns: Not significant, *P < 0.05, **P < 0.01, and ***P < 0.001.

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