Fig. 4: High MRI apparent diffusion coefficient distinguishes Merlin-intact meningiomas with favorable clinical outcomes.
From: MerlinS13 phosphorylation regulates meningioma Wnt signaling and magnetic resonance imaging features
a Example brain magnetic resonance imaging (MRI) T1 post-contrast and apparent diffusion coefficient (ADC) maps. Red dotted lines show meningiomas on ADC maps. Representative of n = 100 meningiomas. b Kaplan-Meier survival curve for local freedom from recurrence in 100 human meningioma patients with pre-operative MRI analysis and post-operative DNA methylation profiling dichotomized at the mean normalized ADC (1.21, log-rank test). c Meningioma DNA methylation groups across ADC high versus ADC low strata from the 100 patients in (b) (Chi-squared test). d CH-157MN xenograft measurements in NU/NU mice with or without doxycycline-inducible Merlin rescue or shRNA suppression of β-catenin (n = 15/condition). e Kaplan-Meier survival curve for CH-157MN xenograft overall survival in NU/NU mice as in (d) (n = 15/condition, log-rank test). f Normalized ADC from MRI of CH-157MN xenografts as in (d, e). g Model of meningioma Wnt signaling in the context of Merlin post-translational modifications, PP1A and PKC activity, cancer-associated missense mutants, and meningioma ADC. Lines represent means, and error bars represent standard error of the means. *P ≤ 0.05, **P ≤ 0.01, ***P ≤ 0.0001 (Student’s t test, one sided). Source data are provided as a Source Data file.
