Table 1 Characteristics of the participants with or without prevalent clonal hematopoiesis of indeterminate potential (CHIP) in the Atherosclerosis Risk in Communities Study

From: Long-term longitudinal analysis of 4,187 participants reveals insights into determinants of clonal hematopoiesis

Characteristics

Without Prevalent CHIP

With Prevalent CHIP

P

N

3730

457

-

Age, mean (SD), y

55.3 (5.4)

57.2 (6.0)

2.7E−10

Sex: Female, n (%)

2226 (59.7)

252 (55.1)

0.07a

Sex: Male, n (%)

1504 (40.3)

205 (44.9)

Race: African American (AA)

865 (23.2)

86 (18.8)

0.04a

Race: European American (EA)

2865 (76.8)

371 (81.2)

Ever Smoker, n (%)

2004 (53.7)

265 (58.0)

0.08

BMI, mean (SD), kg/m2

27.8 (5.1)

27.6 (5.2)

0.40

SBP, mean (SD), mmHg

118.3 (16.3)

119.5 (16.6)

0.14

DBP, mean (SD), mmHg

72.5 (9.8)

72 (9.7)

0.35

Cholesterol medication, n (%)

197 (5.3)

34 (7.5)

0.09

Hypertension, n (%)

1056 (28.4)

138 (30.2)

0.42

T2D, n (%)

305 (8.2)

44 (9.7)

0.31

CHD, n (%)

116 (3.1)

11 (2.4)

0.36

IS, n (%)

38 (1.0)

4 (0.9)

0.78

HF, n (%)

103 (2.8)

10 (2.2)

0.45

Total cholesterol, mean (SD), mg/dl

207.9 (36.3)

209.7 (38.1)

0.35

LDL-C, mean (SD), mg/dl

130.5 (34.4)

131.3 (30)

0.65

HDL-C, mean (SD), mg/dl

52 (16.9)

51.7 (17.9)

0.67

Triglycerides, median (IQR), mg/dl

109.0 (75)

119.0 (76)

0.02b

Follow-up, mean (range), y

20.3 (5–26)

20.1 (6–27)

0.07

  1. P-values are from a two-sided t-test comparing baseline samples with and without prevalent CHIP.
  2. BMI body mass index, CHIP clonal hematopoiesis of indeterminate potential, CHD coronary heart disease, DBP diastolic blood pressure, HDL-C high-density lipoprotein cholesterol, HF heart failure, IQR interquartile range, IS ischemic stroke, LDL-C low-density lipoprotein cholesterol, SBP systolic blood pressure, SD standard deviation, T2D type 2 diabetes.
  3. aP from Pearson’s Chi-squared test.
  4. bP from a two-sided Wilcoxon rank sum test.
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