Fig. 7: Aging is associated with functional and molecular changes in distinct hematopoietic stem cell subsets. | Nature Communications

Fig. 7: Aging is associated with functional and molecular changes in distinct hematopoietic stem cell subsets.

From: Aging is associated with functional and molecular changes in distinct hematopoietic stem cell subsets

Fig. 7

Schematic overview of the age-related functional and molecular changes in CD49b– and CD49b+ HSCs in juvenile, adult, and old mice. Aging is associated with gradually increasing myeloid cellular output in both CD49b– and CD49b+ HSCs. Gene expression profiling detects age-related molecular changes in total HSCs. Chromatin accessibility analysis reveals age-dependent and CD49b subset-specific differences. M-bi myeloid-biased, L-bi lymphoid-biased, Bal balanced.

Back to article page