Fig. 7: Correlation of the murine microbiota post-FMT. | Nature Communications

Fig. 7: Correlation of the murine microbiota post-FMT.

From: The DAV132 colon-targeted adsorbent does not interfere with plasma concentrations of antibiotics but prevents antibiotic-related dysbiosis: a randomized phase I trial in healthy volunteers

Fig. 7

A Compositional histograms of two representative examples of the gut microbiota composition determined with 16S rRNA sequencing for the HV donor collected at D1 or D6 of CZA vs CZA + DVA132 compared to the gut microbiota mice post-FMT with these feces samples at different timepoints; T0 (tumour inoculation), T1 (before start of the treatment) T5 (after four αPD-1 or isotype control cycles). Left panel represents on top the HV1 microbiota composition before (D1) and after (D6) CZA treatment and below, recolonized murine fecal samples collected during experiment. Right panel represents HV5 before (D1) and after (D6) CZA + DAV132 treatment. In the lower panels, each column represents one fecal sample. B Principal coordinates analysis (PCoA) analysis based on Bray–Curtis distances of HV donor and matching murine fecal samples collected after four cycles of αPD-1 or isotype control (D17 on the Fig. 5A). Each color corresponds to one treatment at one timepoint and each shape to one HV donor. A PERMANOVA test was applied to test statistical differences between groups. C Heatmap comparing fecal samples from germ-free mice after two αPD-1 administrations (D12) following FMT from HV donors who were on CZA alone or CZA + DAV132 obtained at D1 or D6. Each column represents one mouse. CZA ceftazidime-avibactam, D day, FMT fecal microbiota transplantation, HV healthy volunteer, PD-1 programmed cell death protein 1, DAV132 DAV132 12 g po tid. Source data are provided as a Source Data file.

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