Fig. 5: Hyperinteracting hubs are more lineage associated compared to regular hubs in T-ALL, MCL, and TNBC.
From: Enhancer-promoter hubs organize transcriptional networks promoting oncogenesis and drug resistance
a Matrix of pairwise SMC1 HiChIP enhancer-promoter hub similarity across T-ALL, MCL, and TNBC cells. Total hub count for each cell line is listed on the left. b Matrix of pairwise SMC1 HiChIP hyperinteracting hub similarity across T-ALL, MCL, and TNBC cells. Total hyperinteracting hub count for each cell line is listed on the left. c, d Gray box-marked KAT5 forms a hyperinteracting enhancer-promoter hub with SMC1 HiChIP arcs connecting active regulatory elements and genes marked with H3K27ac ChIP-seq and RNA-seq, respectively, in T-ALL DND41 and MCL Rec-1 (c) but not TNBC MB157 and HCC1599 (d). Bottom tracks indicate Ensembl gene position. e, f Gray box-marked CEBPB forms a hyperinteracting enhancer-promoter hub with SMC1 HiChIP arcs connecting active regulatory elements and genes marked with H3K27ac ChIP-seq and RNA-seq, respectively, in TNBC MB157 and HCC1599 (f) but not T-ALL DND41 and MCL Rec-1 (e). Bottom tracks indicate Ensembl gene position.
