Fig. 4: Structural basis of hu3.10C2 recognition of TREM2. | Nature Communications

Fig. 4: Structural basis of hu3.10C2 recognition of TREM2.

From: Rapid affinity optimization of an anti-TREM2 clinical lead antibody by cross-lineage immune repertoire mining

Fig. 4

a Crystal structure of TREM2 (148-165) bound by the hu3.10C2 Fab fragment. The heavy chain (VH) is shown in green surface, while the light chain (VL) is depicted in cyan surface representation. The TREM2 peptide is shown in brown stick representation with its N-terminus at the right end. b Zoom-in view of the VL–TREM2 interface. This interface is largely dominated by polar interactions (dotted lines) between the Fab and peptide. c Zoom in view of the VH–TREM2 interface. Fab residue numbering is in the IMGT® system.

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