Table 2 Baseline hemodynamic and renal measures

From: Cardiovascular and renal effects of apelin in chronic kidney disease: a randomised, double-blind, placebo-controlled, crossover study

 

Healthy subjects

CKD

n

12

12

Heart rate, bpm

58 ± 2

59 ± 2

Cardiac index, L/min/m2

2.9 ± 0.1

2.6 ± 0.2

Systemic vascular resistance index, dynes*sec*cm−5 m2

2,429 ± 87

2,862 ± 180

Pulse wave velocity, m/s

5.7 ± 0.3

6.5 ± 0.3

Central augmentation index, %

3.6 ± 3.9

7.5 ± 4.1

Effective renal blood flow, mL/min

824 ± 48

313 ± 49

Effective renal vascular resistance, mmHg/min/L

117 ± 8

405 ± 73

Effective filtration fraction, %

19.5 ± 0.9

20.7 ± 1.2

Glomerular filtration rate, mL/min

96 ± 5

41 ± 5

Urine sodium excretion, μmol/min

217 ± 18

233 ± 23

Protein excretion rate, μg/min

14 (5–127)

192 (70–525)

Free water clearance, mL/min

5.7 ± 0.4

3.9 ± 0.5

  1. The data shown are an average of baseline measurements from each study visit for each participant. Augmentation index has been corrected to 75 bpm. Data are mean±SEM or median (interquartile range).
Back to article page