Fig. 2: Genetic analysis of WGD events in self-reported Black and white cancer patients.

A A volcano plot displaying genetic alterations associated with an increased or decreased likelihood of WGD events across both self-reported Black and white patients in the MSK-MET cohort. Acronyms: Mutant (Mut). B A table displaying 10 events exhibiting the strongest correlation with WGD events among self-reported Black patients. The bolded numbers indicate q-values below 0.05. C A table displaying 10 events exhibiting the strongest correlation with WGD events among self-reported white patients. The bolded numbers indicate q-values below 0.05. D A bar graph displaying the frequency of TP53 mutations across self-reported Black and white cancer patients. E A bar graph displaying the frequency of TP53 mutations across self-reported Black and white patients with either breast cancer, endometrial cancer, or NSCLC. F A bar graph displaying the frequency of WGD events among self-reported Black and white cancer patients, divided based on TP53 status. G A bar graph displaying the frequency of WGD events among self-reported Black and white patients with either breast cancer, endometrial cancer, or NSCLC, divided based on TP53 status. H A bar graph displaying the distribution of different types of TP53 mutations in self-reported Black and white cancer patients. I A bar graph displaying the distribution of different types of TP53 mutations in self-reported Black and white patients with either breast cancer, endometrial cancer, or NSCLC. J A lollipop plot displaying the sites of TP53 mutations in tumors from either self-reported white (top) or Black (bottom) cancer patients. Source data are provided as a Source Data file. Statistical testing was performed via two-tailed Wald test (A–C) with correction by Benjamini-Hochberg’s method (B, C) and two-tailed Pearson’s Chi-squared test (D–I). Statistical significance: NS p ≥ 0.05, * p < 0.05, ** p < 0.01, *** p < 0.001, **** p < 0.0001.