Fig. 4: Clinical correlates of WGD status in self-reported Black and white cancer patients.

A A table displaying the demographics of self-reported Black and white cancer patients in the MSK-MET cohort. B A table displaying the demographics of cancer patients based on WGD status. C A bar graph displaying the frequency of microsatellite instability (MSI-H) among tumors from self-reported Black and white cancer patients. D A bar graph displaying the frequency of microsatellite instability (MSI-H) among cancer patients based on WGD status. E The frequency of metastatic dissemination to different anatomic sites, divided by patient race. Locations written in red are significantly more likely among self-reported Black patients, no locations were more likely among self-reported white patients. For Ovary and Female Genital locations, frequency of metastasis represents female patients only. For Male Genital location, frequency of metastasis represents male patients only. F The frequency of metastatic dissemination to different anatomic sites based on WGD status. Locations written in red are significantly more likely among WGD-positive patients, no locations were more likely among WGD-negative patients. For Ovary and Female Genital locations, frequency of metastasis represents female patients only. For Male Genital location, frequency of metastasis represents male patients only. Central Nervous System (CNS), Lymph Node (LN), Peripheral Nervous System (PNS), Urinary Tract (UT). Statistical testing was performed via two-tailed Wilcoxon rank-sum test (A, B) and two-tailed Pearson’s Chi-squared test (C–F). Source data are provided as a Source Data file. Statistical significance: NS p ≥ 0.05, * p < 0.05, ** p < 0.01, *** p < 0.001, **** p < 0.0001.