Table 1 Determination of antibacterial potency [MIC₉₀ (µg/ml)] of BWC0977 and other known antibiotics performed at the International Health Management Associates (IHMA) against a global collection of Gram-negative drug-resistant clinical isolates

N

298

300

300

300

152

152

151

150

42

45

90

BWC0977

1

1

0.5

2

2

0.5

1

0.25

1

1

≤ 0.016

Ciprofloxacin

> 32

16

ND

> 32

ND

ND

ND

16

ND

ND

> 1

Levofloxacin

> 32

32

16

> 32

64

8

2

8

16

1

ND

^aCefiderocol

4

2

2

2

4

0.5

2

2

1

1

ND

Cefepime

> 32

> 32

> 32

> 32

64

16

> 32

> 32

> 32

> 32

ND

Cefpodoxime

ND

ND

> 32

> 32

64

> 32

> 32

ND

> 32

> 32

ND

Ceftriaxone

ND

ND

ND

ND

ND

ND

ND

ND

ND

ND

0.06

Ceftazidime

> 32

>Z 32

64

> 64

128

2

> 64

> 32

16

8

ND

Ceftazidime-Avibactam

ND

> 16

0.25

1

2

0.06

0.5

ND

0.125

1

ND

Aztreonam

ND

> 16

> 64

> 64

128

0.5

64

ND

16

32

ND

Aztreonam/Avibactam

ND

> 16

0.125

0.25

0.5

≤ 0.016

0.25

ND

0.06

0.25

ND

Piperacillin/Tazobactam

> 128

128

ND

ND

0.06

ND

ND

> 128

ND

ND

ND

Meropenem

> 64

32

≤ 0.06

32

8

0.125

≤ 0.06

> 64

0.125

0.125

ND

Meropenem-vaborbactam

> 32

32

≤ 0.03

16

0.25

0.125

≤ 0.03

> 32

0.06

0.125

ND

Colistin

0.5

1

0.25

0.5

2

> 32

0.5

> 32

64

> 32

ND

Amikacin

 >64

64

8

32

4

4

4

> 64

8

8

ND

Gentamicin

> 32

> 32

> 32

> 32

1

16

8

> 32

64

16

ND

Doxycycline

64

32

32

32

16

> 32

16

4

64

16

ND

Eravacycline

ND

ND

0.25

1

ND

2

0.5

ND

1

2

ND

Tobramycin

> 32

> 32

16

> 32

32

8

8

> 32

16

32

ND

Plazomicin

ND

ND

1

0.5

0.5

4

0.5

ND

8

2

ND