Fig. 1: Manhattan plots of a whole-genome sequencing analysis of height.

Manhattan plots of results split by single variant and genomic aggregate analysis. From top to bottom: unconditioned single variants, single variants conditioned on known height loci, rare ( < 0.1% minor-allele frequency) coding genome aggregates, followed by rare non-coding genome units proximal genome aggregates, regulatory genome aggregates and sliding window aggregates. We plot–log10(p) on the y-axis. Red horizontal lines indicate the position of genome-wide significance considering only that panel, whilst blue indicates genome-wide significance across the entire study. For the single variant, coding and proximal panels, loci leads are labelled by their annotated gene based on the output of the Variant Effect Predictor. All plotted statistics were derived from the discovery UK Biobank analysis set (N = 183,078), based on a two-sided chi-squared statistic.