Fig. 2: Synovial fibroblast signatures during homeostasis. | Nature Communications

Fig. 2: Synovial fibroblast signatures during homeostasis.

From: Adipocyte associated glucocorticoid signaling regulates normal fibroblast function which is lost in inflammatory arthritis

Fig. 2

A Fine clustering analysis on healthy synovial fibroblasts defines seven distinct clusters. B Top markers of each fibroblast cluster. C Heatmap of the top 10 DEGs per cluster. D Symphony mapping of OA, naive RA, and remission (REM) fibroblasts to healthy synovial fibroblast reference. E Quantification of fibroblast proportions mapping to each cluster. Each data point represents a patient sample. Statistical comparisons: all groups were compared to healthy. Healthy: n = 10, OA: n = 9, RA: n = 26, REM: n = 3 biological samples. P values were calculated using an ordinary one-way ANOVA followed by Dunnet’s multiple comparison post hoc testing. F Healthy synovium is enriched in APOD, CEBPD, and NNMT expression compared to OA and RA fibroblasts, and is partially restored in remission fibroblasts. All data are presented as mean ± standard deviation. *P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.0001. Source data are provided as a Source Data file.

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