Fig. 5: Flow-click chemistry.
From: SO2F2 mediated click chemistry enables modular disulfide formation in diverse reaction media
The tube-in-tube flow-click chemistry apparatus and its application to large scale disulfide synthesis. Reaction conditions: the solution of thiol and Et3N was pumped into the outer tube at a rate of 1 mL/min after SO2F2 was introduced into the inner tube. The apparatus operated for 1 h at room temperature.
