Fig. 1: Representative natural products and strategies for synthesizing β-branched aromatic amino acids. | Nature Communications

Fig. 1: Representative natural products and strategies for synthesizing β-branched aromatic amino acids.

From: Direct asymmetric synthesis of β-branched aromatic α-amino acids using engineered phenylalanine ammonia lyases

Fig. 1

a Examples of bioactive compounds containing β-branched aromatic amino acids. b Reported18,19,20,21,22,23,24,25,26 strategies for the biocatalytic synthesis of β-branched aromatic amino acids. c Direct asymmetric amination synthesis method developed in this study. MAL methylaspartate ammonia lyase, AAO amino acid oxidase, TA transaminase, PLP pyridoxal-5’-phosphate, PMP pyridoxamine-5’-phosphate, MT methyltransferase, SAM S-Adenosylmethionine, SAH S-adenosylhomocysteine, THF Tetrahydrofuran, TEPA Triethylphosphonoacetate, PcPAL Phenylalanine ammonia lyase from Petroselinum crispum.

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