Fig. 5: FRTAC targeting PD-L1 inhibits tumor growth in B16F10, CT26 and MOC1 syngeneic mouse models. | Nature Communications

Fig. 5: FRTAC targeting PD-L1 inhibits tumor growth in B16F10, CT26 and MOC1 syngeneic mouse models.

From: Development of folate receptor targeting chimeras for cancer selective degradation of extracellular proteins

Fig. 5

a Schematic illustration of FRTAC treatment in B16F10 mouse model. b Schematic illustration of FRTAC treatment in CT26 mouse model. c Schematic illustration of FRTAC treatment in MOC1 mouse model. d Tumor growth curves after different treatments as indicated by (a) (n = 8). e Tumor growth curves after different treatments as indicated by (b) (n = 10). f Tumor growth curves after different treatments as indicated by (c) (n = 9). g. Body weight curves after different treatments as indicated by (a) (n = 8). h Body weight curves after different treatments as indicated by (b) (n = 10). i Body weight curves after different treatments as indicated by (c) (n = 9). j Images and weight of excised tumors on day 24 after different treatments as indicated by (b) (n = 10). Data are presented as mean ± SD, n = 10. k Images and weight of excised tumors on day 29 after different treatments as indicated by (c) (n = 9). N indicates mice. Data are presented as mean ± SD. The statistical significance was assessed using a paired one-tailed t test for (d–f) and a paired two-tailed t test for (j, k), *P < 0.05, **P < 0.01, ****P < 0.0001. Source data are provided as a Source Data file.

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