Table 1 Specific essential genes identified in multiple myeloma

From: An automated network-based tool to search for metabolic vulnerabilities in cancer

SYMBOL

ENSEMBL

NB (n = 5)

CB (n = 7)

CC (n = 7)

MEM (n = 8)

TPC (n = 5)

BMPC (n = 3)

MM (n = 37)

CoMMpass (n = 767)

CCLE (n = 8)

CTPS1

ENSG00000171793

0%

0%

0%

0%

0%

0%

11%

71%

88%

NMNAT3

ENSG00000163864

0%

0%

0%

0%

0%

0%

19%

29%

13%

PC

ENSG00000173599

0%

0%

0%

0%

0%

0%

32%

18%

88%

UAP1

ENSG00000117143

0%

0%

0%

0%

0%

0%

16%

14%

38%

  1. These genes are predicted essential in a sufficient percentage of samples of our MM cohort and MMRF-CoMMpass, but not in the samples of different B-cell subpopulations obtained from healthy donors: bone marrow plasma cells (BMPC), tonsil plasma cells (TPC), memory B cells (MEM), centrocytes (CC), centroblasts (CB), naïve B cells (NB). Units are the percentage of predicted samples in which a gene is essential.