Fig. 5: VLDLR immunoreactivity in human liver tissue. | Nature Communications

Fig. 5: VLDLR immunoreactivity in human liver tissue.

From: A sexually dimorphic hepatic cycle of periportal VLDL generation and subsequent pericentral VLDLR-mediated re-uptake

Fig. 5

H-DAB VLDLR immunostainings and corresponding diagnostic H&E sections from the same FFPE block. Samples were grouped by sex and age, with the younger group consisting of premenopausal female donors and age matched males (≤ 49 years). Based on the quantified DAB signal, non-pathological samples with the median immunoreactivity were chosen for representative images. For each representative sample, a lower magnification overview and a higher magnification image are shown. Rectangles mark the magnified area. The H-DAB stainings show VLDLR immunoreactivity around the central veins in all samples. The highest DAB stain intensity is seen in premenopausal females (n = 33 donors; CV central vein, PV portal vein, PT portal tract).

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