Fig. 4: Rhythms remain diminished in pathological tissue across time and independent of seizure occurrence.
From: Diminished circadian and ultradian rhythms of human brain activity in pathological tissue in vivo
a–c Example subject A: (a) The power of the circadian rhythm of delta across ROIs. Each cell represents the power of the circadian rhythm in the corresponding ROI and 30 s time segment. ROIs in red are deemed pathological. b The median AUC of the circadian rhythm captured using a rolling window of 36 hours. The peri-ictal period (1 hour before seizure start to 1 hour after its end) is shown in orange. The histogram shows the distribution of AUC values calculated during peri-ictal and inter-ictal periods. c Compares rolling AUC values calculated during inter-ictal and peri-ictal periods for each circadian and ultradian rhythm of delta power. A two-sided paired Student’s t test, with no correction for multiple comparisons indicates no difference between periods for each rhythm. Dashed lines indicate median and quartiles of the distribution. Source data are provided as a Source Data file.
