Fig. 6: Model for TPSN regulation by the RNF185/MBRL ERAD complex. | Nature Communications

Fig. 6: Model for TPSN regulation by the RNF185/MBRL ERAD complex.

From: Tapasin assembly surveillance by the RNF185/Membralin ubiquitin ligase complex regulates MHC-I surface expression

Fig. 6

The RNF185/MBRL complex degrades a pool of unassembled TPSN, thereby limiting the amount available for assembly onto the PLC. RNF185/MBRL-dependent degradation involves the recognition of evolutionary conserved lysine residue in the TPSN transmembrane segment that is also essential for its assembly with TAP1 and TAP2. The absence of RNF185/MBRL results in elevated TPSN levels. These stabilize its partners TAP1 and TAP and ultimately result in increased levels of MHC-I. See text for details.

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