Fig. 5: Comparison of mouse pharmacokinetic data of enzalutamide. | Nature Communications

Fig. 5: Comparison of mouse pharmacokinetic data of enzalutamide.

From: Sol-moiety: Discovery of a water-soluble prodrug technology for enhanced oral bioavailability of insoluble therapeutics

Fig. 5

a Plasma concentrations of enzalutamide were measured over a 72-hour time course. Enzalutamide was dosed intravenously using a standard DMSO-based formulation and orally using a carboxymethylcellulose/Tween 80 suspension, and PO dosing of Sol-enzalutamide 1i and 1iii was performed using deionized water as a vehicle. n = 3 mice per dose group. Line data represents mean values at each time point. Individual values per mice are shown. b Bar chart to show the difference in oral bioavailability observed for enzalutamide comparing a standard formulation and delivery due to Sol-enzalutamide 1i and 1iii. n = 3 mice per dose group. Data are presented as mean values +/− SD. Statistical significance determined using an ordinary one-way ANOVA with Tukey’s multiple comparison test. Mouse image Created in BioRender. Smith, M. (2024) BioRender.com/y69d862.

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