Fig. 6: Comparison of alkaline phosphatase, Caco-2 and mouse pharmacokinetic data using the Sol-moiety-drug conjugates 1i, 1iii, 1iv and 1 v. | Nature Communications

Fig. 6: Comparison of alkaline phosphatase, Caco-2 and mouse pharmacokinetic data using the Sol-moiety-drug conjugates 1i, 1iii, 1iv and 1 v.

From: Sol-moiety: Discovery of a water-soluble prodrug technology for enhanced oral bioavailability of insoluble therapeutics

Fig. 6

Compounds were dosed at an equivalent of 5 mg/kg of enzalutamide in saline solution and plasma concentrations measured over 24 h. n = 3 mice per dose group. Line data represents mean values at each time point. Mouse image Created in BioRender. Smith, M. (2024) BioRender.com/y69d862.

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