Fig. 2: Efficiency of metabolic networks, in aerobic (Fig. 2b) and anaerobic conditions (Fig. 2c), and of the genetic interaction network (under aerobic conditions only) upon deletion of seven NED or non-NED genes (Fig. 2a).
From: Minimisation of metabolic networks defines a new functional class of genes
The horizontal dashed lines correspond to the efficiency of the networks when all of the magnificent seven genes have been removed. Bounds of boxes defined as Q1 - Q3, i.e. 25th − 75th percentile; bounds of whiskers defined as Q1-1.5xIQR - Q3 + 1.5xIQR. A Mann-Whitney two-sided test was used for statistical significance. All p-values are below 2e-16. A full account of the statistical basis of these box plots is given in Supplementary Data 8. (Supplementary Figs. 13–15 provide the results of classical network topology analyses, e.g. average degree and weight distributions. Readers may visualise the impact of minimisation on network topology by referring to the metabolic maps, Supplementary Figs. 8–12, a link to the files that will enable readers to generate their own maps is also provided). Source data are provided as four Source Data files: Fig. 2 Statistical Data Boxplot.docx, Fig. 2a Source Data.csv, Fig. 2b Source Data.csv and Fig. 2c Source Data.csv.
