Table 1 Transcription errors affect proteins directly implicated in amyloid- and prion-like diseases
From: Transcript errors generate amyloid-like proteins in human cells
Gene | Protein | Disease | Errors detected | Mutations mimicked | Key aa’s affected | Amyloid potential ⇧ |
|---|---|---|---|---|---|---|
ABri peptide | ITM2B | FBD and FDD | 66 | 2 | 6 | 27 |
Amyloid precursor protein | APP | Alzheimer’s disease | 266 | 6 | 9 | 51 |
Cystatin-B | CSTB | EPM1 | 33 | 2 | 1 | 0 |
Fused in sarcoma | FUS | ALS | 25 | 1 | 3 | 10 |
Gamma-crystallin D | CRYGD | Coralliform cataracts | 1 | 1 | 0 | 0 |
Gelsolin | GSN | FAF | 35 | 1 | 1 | 12 |
Heterogeneous nuclear ribonucleoprotein D-like | HNRNPDL | Limb-girdle muscular dystrophy 1 G | 15 | 1 | 1 | 4 |
Medin | MFGE8 | Cerebrovascular dysfunction | 115 | 1 | 1 | 29 |
Neurofilament heavy polypeptide | NEFH | CMT and ALS | 1 | 1 | 0 | 1 |
Prion protein | PRNP | CJD, GSS, FFI | 10 | 1 | 1 | 1 |
Receptor-interacting serine/threonine-protein kinase 1 | RIPK1 | Neuroinflammation | 1 | 1 | 0 | 1 |
Solute carrier family 3 Member 2 | SLC3A2 | Lysinuric protein intolerance | 57 | 1 | 0 | 8 |
Super oxide dismutase 1 | SOD1 | ALS | 6 | 1 | 0 | 1 |
Transforming growth factor beta-induced | TGFBI | Corneal dystrophy | 701 | 6 | 12 | 126 |
Tumor protein 53 | TP53 | Cancer | 60 | 5 | 1 | 3 |
Transthyretin | TTR | Transthyretin amyloidosis | 57 | 4 | 9 | 12 |
Tubulin alpha-1A chain | TUBA1A | Tubulinopathies | 149 | 3 | 15 | 33 |
