Table 2 Transcription errors affect proteins with prion-like domains

From: Transcript errors generate amyloid-like proteins in human cells

Gene

Protein

PrlD

Errors detected

Errors in PrlD

Prion potential ↑ 

Annexin A11

ANXA11

41-177

25

6

3

Cell Cycle Associated Protein 1

CAPRIN1

466-628

59

14

20

DEAD-Box Helicase 5

DDX5

531-614

64

3

14

DEAD-Box Helicase 17

DDX17

614-719

46

4

9

Ewing Sarcoma breakpoint region 1

EWSR1

1-256

68

21

17

Fused in Sarcoma

FUS

1-239

35

8

11

Heterogeneous nuclear ribonucleoprotein A0

HNRNPA0

206-305

23

7

3

Heterogeneous nuclear ribonucleoprotein A1

HNRNPA1

190-307

167

19

27

Heterogeneous nuclear ribonucleoproteins A2/B1

HNRNPA2B1

197-353

38

6

12

Heterogeneous nuclear ribonucleoprotein A3

HNRNPA3

207-378

36

6

14

Heterogeneous nuclear ribonucleoprotein D0

HNRNPD

195-260

53

3

9

Heterogeneous nuclear ribonucleoprotein H3

HNRNPH3

268-346

15

3

4

Heterogeneous nuclear ribonucleoprotein U

HNRNPU

683-825

132

6

15

Heterogeneous nuclear ribonucleoprotein U

HNRNPU

683-825

132

6

15

Heterogeneous nuclear ribonucleoprotein U-like 1

HNRNPUL1

531-766

105

9

17

Heterogeneous nuclear ribonucleoprotein U-like 2

HNRNPUL2

641-747

21

4

5

Interleukin enhancer-binding factor 3

ILF3

661-894

67

7

19

Nuclear receptor coactivator 1

NCOA1

908-1198

8

3

5

Nuclear factor of activated T-cells 5

NFAT5

999-1454

12

6

4

Nucleoporin 153

NUP153

1322-1453

23

4

4

Polyhomeotic Homolog 1

PHC1

7-104

103

8

5

R3H domain-containing protein 2

R3HDM2

394-714

8

3

3

SRY-Box Transcription Factor 2

SOX2

154-231

14

4

0

TAR DNA-binding protein 43

TARDBP

277-414

35

3

5

TRK-fused gene protein

TFG

223-400

24

8

6

Yip1 domain family member 5;

YIPF5

1-85

12

4

1

Zinc Finger MIZ-Type Containing 1

ZMIZ1

248-403

24

4

5

  1. Column 1: Gene name. Column 2: Protein symbol. Column 3: Location of prion-like domain inside protein. Column 4: Number of errors detected in transcripts that were derived from this gene. Column 5: Number of errors that affect the prion-like domain. Column 6: The number of errors that increase the prion-like potential of these proteins as predicted by bioinformatic analysis (PAPA)