Fig. 3: Correlation of mean AFs and known melanoma biomarkers. | Nature Communications

Fig. 3: Correlation of mean AFs and known melanoma biomarkers.

From: Tumour-informed liquid biopsies to monitor advanced melanoma patients under immune checkpoint inhibition

Fig. 3

A, B and C show the mean allele fraction of patient-specific variants in liquid biopsy samples from patients under palliative combined ICI and S100 (µg/l), LDH (U/l) and MTV (ml). The Spearman’s rank correlation coefficients were calculated to determine the correlation between AF and S100 (rho = 0.72, t = 8.17, df = 62, p = 2.01 × 10−9), LDH (rho = 0.54, t = 5.06, df = 62, p = 4.12 × 10−4) and MTV (rho = 0.69, t = 7.26, df = 58, p = 1.1 × 10−6). Axes were log transformed and the minimum of all non-zero values was divided by two and added to zero values. S100 - µg/l, LDH - U/l, MTV - ml. Source data are provided as a Source Data file.

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