Fig. 1: Microbiome composition correlates with susceptibility to febrile malaria in children and high parasite burden in mice.
From: The gut microbiome is associated with susceptibility to febrile malaria in Malian children
A Principal coordinate analysis (PCoA) plot of the Bray-Curtis dissimilarity of the human fecal samples using 16S rRNA sequencing. Gavage samples are highlighted by increased point size. B Parasitemia and C AUC of the gavaged gnotobiotic mice by resistant and susceptible outcome groups, and D parasitemia by individual gavage groups. n = 4 mice for each donor used. n = 16 for the overall resistant and susceptible groups. PCoA plots of the Bray-Curtis dissimilarity for the E human and the F murine fecal samples using 16S rRNA sequencing and the updated resistant definition. The P value for the Bray–Curtis distance was determined using a two-sided PERMANOVA, and the P value for the parasitemia was determined using a two-sided Mann–Whitney U test. Blue circles indicate resistant children or low parasitemia mice, and red circles indicate susceptible children or high parasitemia mice. Mean ± standard error of the mean (SEM) indicated for parasitemia and AUC.
