Fig. 2: Cryo-EM structures of FMDV in complex with M678F or M688F. | Nature Communications

Fig. 2: Cryo-EM structures of FMDV in complex with M678F or M688F.

From: Foot-and-mouth disease virus antigenic landscape and reduced immunogenicity elucidated in atomic detail

Fig. 2

a Cryo-EM maps of FMDV 146S-M678F-complex (left), FMDV 146S-M688F-complex (middle) and 146S-M678F-M688F complex (right). The FMDV 146S capsids of the complexes are colored by radius scheme as shown by the color bar below; M678F and M688F are colored in lavender and magenta, respectively. b Footprints of M678F and M688F on the surface of FMDV 146S. Residues of VP1, VP2, and VP3 are colored in blue, green, and red, respectively. Residues involved in binding to VHHs are outlined in brighter colors corresponding to the protein chain they belong to. The footprints of M678F and M688F are indicated by lavender and magenta lines, respectively. c Surface representation (left) and epitopes (right) of M678F and M688F on a pentamer of FMDV 146S. The 146S pentamers are shown as surface (left) or cartoon (right) in the signature colors (VP1, blue; VP2, green; VP3, red), while M678F and M688F are colored in accordance with panel a. The epitopes of M678F (left) and M688F (right) are shown as spheres and those from one epitope are circled by yellow lines. d Structural basis of M678F and M688F binding to FMDV 146S. Loops from FMDV 146S involved in interactions with M678F or M688F are shown as ribbon, while the remaining parts are shown as cartoon. M678F and M688F are represented as ribbon. The color scheme is the same as in panel (a). e Detailed interactions of FMDV 146S with M678F (left), or M688F (right). Residues involved in the binding are shown as sticks and hydrogen bonds are shown as yellow dashed lines.

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