Table 1 ITC analysis of OC2, CUT and HOX binding to the PEG10 DNA
From: The homeodomain regulates stable DNA binding of prostate cancer target ONECUT2
Interaction | KD (nM) | ΔG (kcal/mol) | ΔH (kcal/mol) | -TΔS (kcal/mol) | N (sites) |
|---|---|---|---|---|---|
OC2 - PEG10 | 7 ± 2 | −11.2 ± 0.2 | −15.5 ± 0.3 | 4.4 ± 0.2 | 1.0 ± 0.1 |
CUT - PEG10 | 2030 ± 262 | −7.8 ± 0.1 | −3.4 ± 0.2 | −4.4 ± 0.3 | 1.2 ± 0.1 |
(CUT + HOX) - PEG10 | 1380 ± 279 | −8.0 ± 0.1 | −15.0 ± 1.1 | 7.0 ± 1.0 | 1.2 ± 0.2 |
