Table 3 ITC analysis of the binding of OC2 mutants to the PEG10 DNA
From: The homeodomain regulates stable DNA binding of prostate cancer target ONECUT2
Interaction | KD (nM) | ΔG (kcal/mol) | ΔH (kcal/mol) | -TΔS (kcal/mol) | N (sites) |
|---|---|---|---|---|---|
OC2SQ - PEG10 | 51 ± 9 | −10.4 ± 0.7 | −10.7 ± 0.5 | 0.7 ± 0.5 | 0.9 ± 0.1 |
OC2N - PEG10 | 70 ± 11 | −9.8 ± 0.1 | −9.5 ± 0.4 | −0.2 ± 0.5 | 1.0 ± 0.1 |
OC2RR - PEG10 | 47 ± 8 | −10.0 ± 0.1 | −18.7 ± 0.5 | 8.7 ± 0.5 | 0.9 ± 0.3 |
