Fig. 5: Affinity of pyrazines and pyrazinones towards human GPCRs.
From: Mucosal sugars delineate pyrazine vs pyrazinone autoinducer signaling in Klebsiella oxytoca
a Heatmap depicting the activation of 314 human GPCRs by compounds 3 and 3-Homo (100 µM) as analyzed by PRESTO-Tango. The right image illustrates a zoomed in region of the heatmap centered around the histamine receptors. b Dose-response curves of compounds 3, 3-Homo, 6, 7, 9-Me, and histamine against the GPCRs HRH1, HRH2, HRH3, and HRH4 (n = 3 biological replicates). Luminescence was measured in relative luminescence units (RLUs). Data are represented as mean values +/– SD.
