Fig. 5: Mechanistic model of proton transport in the antiporter modules. | Nature Communications

Fig. 5: Mechanistic model of proton transport in the antiporter modules.

From: Dissected antiporter modules establish minimal proton-conduction elements of the respiratory complex I

Fig. 5

Schematic model of (a) antiporter-mediated proton transport. Blue/grey lines schematically show conneted/disconnected proton wires, and red dotted line an electrostatic repulsion. Blue/red/white circles – putative positive/negative/neutral protonation states. pKaA – pKa of N-side proton acceptor; pKaD – pKa of P-side proton donor; ΔGO→C – free energy closing ion pair; pHout – pH of N-side; pHin – pH of P-side. b Comparison of a proton pumping model in the intact Complex I.

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