Fig. 2: Eight transcriptionally distinct tissues in adult liver fluke cross sections. | Nature Communications

Fig. 2: Eight transcriptionally distinct tissues in adult liver fluke cross sections.

From: Spatial transcriptomics of a parasitic flatworm provides a molecular map of drug targets and drug resistance genes

Fig. 2

a DotPlot showing expression profiles of the top 6 marker genes (sorted by ā€œpredictive powerā€) for all eight tissues in the spatial transcriptomics dataset. Dot color encodes the average expression level (mean of UMI counts, normalized and scaled) across all spots within a cluster. Dot size encodes the percentage of spots within a cluster that have captured this transcript. b, c Gene ontology analysis of marker genes (top 75% per cluster) revealed characteristic biological processes (b) and molecular functions (c) for each cluster. Overrepresented functional terms for each cluster were identified using a two-sided Fisherā€™s exact test (p-value < 0.05). Bars for individual clusters are colored according to legend and labeling in (a). For STRING analyses of marker genes of the ovary and testis clusters, see Supplementary Fig.Ā 7. aā€“c Source data are provided as a Source Data file.

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