Table 2 Cox proportional model incorporating time-varying covariates

From: Identifying septic shock subgroups to tailor fluid strategies through multi-omics integration

Variables

HR [95% CI]

p

Recmd_Actual*: Liberal_Liberal

Reference

 

Recmd_Actual: Liberal_Restrict

5.00 [2.40, 10.44]

<0.001

Recmd_Actual: Restrict_Liberal

3.50 [1.87, 6.54]

<0.001

Recmd_Actual: Restrict_Restrict

0.91 [0.82, 1.53]

0.996

Age (for each 1-year increase)

1.02 [1.00, 1.04]

0.049

SOFA (for each 1-point increase)

1.07 [1.00, 1.15]

0.065

Lactate (for each 1 mmol/l increase)

1.26 [1.17, 1.36]

<0.001

  1. *Recmd_Actual: in this study, patients underwent categorization into four distinct groups according to the fluid strategy either recommended or actually administered. For instance, the classification “Liberal_Liberal” denotes that a patient received a liberal fluid strategy as per actual treatment, with the algorithm also recommending the same strategy. Similarly, “Liberal_Restrict” indicates that although the patient is currently undergoing a restrictive fluid strategy, the algorithm suggested a liberal approach. Two-sided p-values are reported.
  2. SOFA sequential organ failure assessment, HR hazard ratio.
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