Fig. 1: DevCCF overview. | Nature Communications

Fig. 1: DevCCF overview.

From: Developmental mouse brain common coordinate framework

Fig. 1

a Morphology and intensity averaged templates from light sheet fluorescence microscopy (LSFM; blue box) and magnetic resonance imaging (MRI; orange block) imaging. The LSFM template was aligned to the undistorted MRI template via multimodal registration. b Multimodal DevCCF with anatomical segmentations is established at four embryonic and three postnatal ages. c Sagittal slices of multimodal E15.5 data registered to the E15.5 DevCCF, each highlighting unique anatomical features. Data includes MRI DWI (red), MRI FA (orange), LSFM GABAergic neurons from Gad2-Cre;Ai14 mice (yellow), LSFM autofluorescence (green), in situ hybridization (ISH) Lhx2 and Foxp2 gene expression (blue), DevCCF annotations (violet), Compiled colocalized data from each data type, as labeled. Scale bar = 2 mm. a, b created in BioRender. Kim, Y. (2023) BioRender.com/q01q598.

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