Fig. 1: GAD-specific responses are detected in T1D patients and healthy donors through different orthogonal methodologies. | Nature Communications

Fig. 1: GAD-specific responses are detected in T1D patients and healthy donors through different orthogonal methodologies.

From: Physiological and pathogenic T cell autoreactivity converge in type 1 diabetes

Fig. 1

a, b Scatter plot for IFN-γ and IL-10 ELISPOT stimulation indexes (SI) against GAD in HD (a) and T1D patients (b). Dashed lines represent the thresholds for positivity (SI = 3). c Classification of ELISPOT responses. Shown are percentages of total. Two-sided chi square test (p > 0.05). d Frequency of CD154+ CD69+ cells from 10 HD and 11 T1D patients after no stimulation (“no antigen”), stimulation with GAD or with SEB. Two-sided Mann Whitney U or unpaired t test. e Phenotype of GAD-specific CD154+ CD69+ cells from 10 HD and 11 T1D patients (Two-sided Mann Whitney U test. p > 0.05). TN: true naïve. CM: central memory. EM: effector memory. Tscm: stem cell-like memory. Blue: HD. Red: T1D patient. Error bars represent standard deviations.

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