Fig. 6: GAD-specific amino acid clonotypes are public and convergent in TN and CM peripheral immune cell subsets.
From: Physiological and pathogenic T cell autoreactivity converge in type 1 diabetes
We browsed the GAD-specific TCRB CDR3 amino acid clonotypes into 31 TN (a) and 31 CM (b) peripheral immune cell repertoires. We classified these repertoires into GAD tandem cohort (if both single-cell and deep sequencing took place) and NGS-only cohort (if we only performed deep sequencing). Colour represents the frequency of the tracked back clonotypes in the periphery, while dot size represents the numbers of unique TCRB CDR3 nucleotide sequences coding for each given amino acid clonotype (convergence).
