Fig. 7: Some GAD-specific amino acid clonotypes are public in Treg and Tscm peripheral immune cell subsets.
From: Physiological and pathogenic T cell autoreactivity converge in type 1 diabetes
We browsed the GAD-specific TCRB CDR3 amino acid clonotypes into 16 Treg (a) and 16 Tscm (b) peripheral immune cell repertoires. We classified these repertoires into GAD tandem cohort (if both single-cell and deep sequencing took place) and NGS-only cohort (if we only performed deep sequencing). Colour represents frequency of the tracked back clonotypes in the periphery, while dot size represents numbers of unique TCRB CDR3 nucleotide sequences coding for each given amino acid clonotype (convergence).
