Fig. 4: General overview of RNAPII CTD sequence and structural features, which have influence on RNAPII CTD phase-separation. | Nature Communications

Fig. 4: General overview of RNAPII CTD sequence and structural features, which have influence on RNAPII CTD phase-separation.

From: Sequence and structural determinants of RNAPII CTD phase-separation and phosphorylation by CDK7

Fig. 4

A model of a droplet containing the CTD of RNAPII highlights the interacting tyrosine sticker residues separated by spacers (middle). Spacers can adopt distinct β-turns depending on the cis-trans proline isomerization (left). RNAPII CTD droplet dissolution upon phosphorylation by the CDK7 complex (right). Letters in colored circles designate amino acid residues of the CTD heptad repeat. Peptides were drawn in ChemSketch (Freeware) 2024.1.1 (Advanced Chemistry Development, Inc).

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