Table 4 Detailed Statistics for Fig. 5

From: Transient nicotine exposure in early adolescent male mice freezes their dopamine circuits in an immature state

N	Test	Factor	Statistic	Statistic Value	p value	Corresponding Figure
A - CPP to 0.2 mg/kg nicotine - naive adolescents
SAL = 17, NIC = 19	Shapiro-Wilk normality test		W	0.9712	0.4605	Fig. 4A center
	One Sample t test	SAL difference from 0	t	−0.7875	0.4425
	One Sample t test	NIC difference from 0	t	2.7048	0.0145
	Welch Two Sample t test	SAC vs NIC	t	2.3317	0.0262
B - CPP to 0.2 mg/kg nicotine - naive adults
SAC = 12, NIC = 12	Shapiro-Wilk normality test		W	0.8885	0.0124	Fig. 4A right
	One Sample t-test	SAC difference from 0	t	0.3367	0.7427
	One Sample t-test	NIC difference from 0	t	0.2286	0.8234
	Welch Two Sample t-test	SAC vs NIC	t	−0.0797	0.9372
C - % time in open arms of EOM - naïve adolescent animals
SAL = 9, NIC = 10,	Shapiro-Wilk normality test		W	0.9832	0.6108	Fig. 4B center
	Welch Two Sample t-test	NIC vs. SAC in 0−3 min	t	0.6447	0.9308^*
	Welch Two Sample t-test	NIC vs. SAC in 3−6 min	t	0.7492	0.9308^*
	Welch Two Sample t-test	NIC vs. SAC in 6−9 min	t	−1.2011	0.7408^*
D - % time in open arms of EOM - naïve adult animals
SAL = 12, NIC = 14,	Shapiro-Wilk normality test		W	0.8876	0.0000	Fig. 4B right
	Wilcoxon rank sum test with continuity correction	NIC vs. SAC in 0−3 min	W	104.0000	0.3159^*
	Wilcoxon rank sum test with continuity correction	NIC vs. SAC in 3−6 min	W	51.0000	0.1891^*
	Wilcoxon rank sum test with continuity correction	NIC vs. SAC in 6−9 min	W	35.0000	0.0377^*
E - % time in open arms of EOM - DREADDS
MCH + SAL = 11, MCH + NIC = 10,	Shapiro-Wilk normality test		W	0.7376	0.0000	Fig. 4C
HM4 + SAL = 11, HM4 + NIC = 14	Kruskal-Wallis rank sum test	All groups, 0−3 min	Kruskal-Wallis chi-squared	1.7264	0.6311
	Kruskal-Wallis rank sum test	All groups, 3−6 min	Kruskal-Wallis chi-squared	18.0767	0.0004
	Kruskal-Wallis rank sum test	All groups, 6−9 min	Kruskal-Wallis chi-squared	16.4805	0.0009
	Wilcoxon rank sum test with continuity correction	HM4-SAL vs HM4-NIC, 3−6 min	W	1.0000	0.0033^*
	Wilcoxon rank sum test with continuity correction	MCH-SAL vs MCH-NIC, 3−6 min	W	29.0000	0.1846^*
	Wilcoxon rank sum test with continuity correction	MCH-SAL vs HM4-SAL, 3−6 min	W	56.0000	0.1846^*
	Wilcoxon rank sum test with continuity correction	MCH-NIC vs HM4-NIC, 3−6 min	W	21.0000	0.3423^*
	Wilcoxon rank sum test with continuity correction	HM4-SAL vs HM4-NIC, 6−9 min	W	1.0000	0.0040^*
	Wilcoxon rank sum test with continuity correction	MCH-SAL vs MCH-NIC, 6−9 min	W	28.0000	0.1368^*
	Wilcoxon rank sum test with continuity correction	MCH-SAL vs HM4-SAL, 6−9 min	W	37.0000	0.1368^*
	Wilcoxon rank sum test with continuity correction	MCH-NIC vs HM4-NIC, 6−9 min	W	18.0000	0.5915^*

^*Holm correction for multiple comparisons.

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Table 4 Detailed Statistics for Fig. 5

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