Fig. 1: Study overview.
From: Prevalent and persistent new-onset autoantibodies in mild to severe COVID-19
Healthcare workers (HCW, n = 478) and patients (n = 48) with complete sample sets from May 2020 to Sept 2021 were selected for the study. Longitudinal serological profiles of anti-spike (S) and anti-nucleocapsid (N) immunoglobulin G (IgG) were obtained using our in-house SARS-CoV−2 serology assay. Proteome-wide planar and bead arrays were used to chart the IgG autoantibody repertoire across seroconversion for the identification of new-onset autoantibodies. Tiled peptide bead arrays were used to identify the main epitopes of selected new-onset autoantibodies and validate them in independent cohorts of Neuro-COVID patients (n = 25) and pre-pandemic healthy controls (HC, n = 29).
