Fig. 2: CR-related activity pattern that moderates effects of pathology.
From: Cognitive reserve against Alzheimer’s pathology is linked to brain activity during memory formation
A Activation (hot colors) and deactivation (cool colors) during encoding of subsequently remembered compared to subsequently forgotten stimuli as identified by t-contrasts of the subsequent memory regressor in the whole fMRI sample. T values of voxels with pFWE < 0.05 are shown. B Group-level CR-related activity pattern that when expressed minimizes effects of AD pathology on cognitive performance as identified via a multivariate approach. The net contribution (moderation coefficient; positive/hot and negative/cool colors) of every voxel to the CR pattern is displayed (unthresholded). C Atrophy pattern in the whole baseline DELCODE sample as obtained by a VBM GM analysis of CN participants vs ADD patients. T values of voxels with pFWE < 0.05 are shown. Source data are provided as a Source Data file. ADD Alzheimer’s disease dementia, CN cognitively normal, CR cognitive reserve, GM gray matter, VBM voxel-based morphometry.
