Table 2 Significant clusters in CR-related activity pattern

From: Cognitive reserve against Alzheimer’s pathology is linked to brain activity during memory formation

#

Mean wi

Size (voxels)

% concordant

Peak (x, y, z)

Peak structure

1

0.100

623

100

49, −63, −17

Temporal_Inf_R

2

0.085

594

100

−49, −66, −17

Occipital_Inf_L

3

0.055

149

79.19

49, 14, 28

Frontal_Inf_Oper_R

4

0.075

119

93.28

−49, 25, 24

Frontal_Inf_Tri_L

5

−0.105

873

90.38

0, −60, 32

Precuneus_L

6

−0.067

235

97.45

−45, −63, 35

Angular_L

7

−0.048

213

100

52, −56, 39

Parietal_Inf_R

  1. Structures and peak voxels were identified in MRIcroGL, using the AAL (Automated Anatomical Labeling) atlas76. wi refers to the CR coefficient of a voxel i. % concordant refers to the proportion of voxels in the cluster that have the same valence (sign) for the CR coefficient and the parametric subsequent memory contrast coefficient as shown in Fig. 4. A concordant region is one where a higher (lower) activity reduces effects of pathology and which is typically activated (deactivated) during the task. Clusters smaller than 50 voxels (voxel size: 3.5 × 3.5 × 3.5 mm3) have been omitted. It is important to note that the CR pattern is multivariate in nature, interpretable as a whole and cluster descriptives are reported for transparency of obtained non-negligible coefficients contributing to the pattern. Source data are provided as a Source Data file.
  2. CR cognitive reserve.
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